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Abstract
BACKGROUND
We recently introduced a policy to use O positive red cells in emergency transfusions for males >16 years of age and females >50 years of age. Here, we investigate changes in emergency transfusion practice and rates of red cell alloimmunization with the use of O positive blood for emergency transfusion.
STUDY DESIGN AND METHODS
State-wide retrospective review of emergency transfusions between June 2020 and June 2021. The laboratory information system and patient medical records were used to collect demographic details, indications for transfusion, usage of O positive and O negative blood and rates of alloimmunization.
RESULTS
There were 2354 red cell units transfused to 1013 patients (male = 59%, average age = 53 years) during the 12-month period. O positive units accounted for 46.9% (1103 units) of emergency transfusions. However, 726 (30.8%) O negative units were transfused to patients without a mandatory indication for O negative blood. Twenty-eight patients (2.9%) had a red cell alloantibody prior to transfusion including anti-E (n = 10), anti-D (n = 4), and anti-K (n = 4). One patient with prior anti-D had mild delayed hemolysis. There were 19 patients (4.3%, median follow-up 22 days) who developed a red cell alloantibody after emergency transfusion and include anti-E (n = 10), anti-D (n = 7), and anti-C (n = 5).
DISCUSSION
The use of O positive blood for emergency transfusion has saved 1103 O negative red cell units with no detriment to patient outcome. There remains potential to optimize use of O positive blood in emergency transfusion and to understand red cell alloimmunization rates in a prospective fashion.
Authors+Show Affiliations
Princess Alexandra Hospital, Pathology Queensland, Brisbane, Australia.
Central Pathology Laboratory (Royal Brisbane and Women's Hospital), Pathology Queensland, Brisbane, Australia.
Central Pathology Laboratory (Royal Brisbane and Women's Hospital), Pathology Queensland, Brisbane, Australia.
Townsville University Hospital, Pathology Queensland, Townsville, Australia.
Pub Type(s)
Journal Article
Language
eng
PubMed ID
37698202
Citation
Chowdhury, Rakin, et al. "Quality Improvement Review of O Positive Blood in Emergency Transfusion." Transfusion, vol. 63, no. 10, 2023, pp. 1841-1848.
Chowdhury R, Williams BA, Williams S, et al. Quality improvement review of O positive blood in emergency transfusion. Transfusion. 2023;63(10):1841-1848.
Chowdhury, R., Williams, B. A., Williams, S., & Casey, J. (2023). Quality improvement review of O positive blood in emergency transfusion. Transfusion, 63(10), 1841-1848. https://doi.org/10.1111/trf.17537
Chowdhury R, et al. Quality Improvement Review of O Positive Blood in Emergency Transfusion. Transfusion. 2023;63(10):1841-1848. PubMed PMID: 37698202.
* Article titles in AMA citation format should be in sentence-case
TY - JOURT1 - Quality improvement review of O positive blood in emergency transfusion.AU - Chowdhury,Rakin,AU - Williams,Bronwyn A,AU - Williams,Sue,AU - Casey,John,Y1 - 2023/09/12/PY - 2023/07/08/revisedPY - 2023/02/23/receivedPY - 2023/07/28/acceptedPY - 2023/9/12/pubmedPY - 2023/9/12/medlinePY - 2023/9/12/entrezKW - O positiveKW - emergencyKW - red cellsKW - transfusionSP - 1841EP - 1848JF - TransfusionJO - TransfusionVL - 63IS - 10N2 - BACKGROUND: We recently introduced a policy to use O positive red cells in emergency transfusions for males >16 years of age and females >50 years of age. Here, we investigate changes in emergency transfusion practice and rates of red cell alloimmunization with the use of O positive blood for emergency transfusion. STUDY DESIGN AND METHODS: State-wide retrospective review of emergency transfusions between June 2020 and June 2021. The laboratory information system and patient medical records were used to collect demographic details, indications for transfusion, usage of O positive and O negative blood and rates of alloimmunization. RESULTS: There were 2354 red cell units transfused to 1013 patients (male = 59%, average age = 53 years) during the 12-month period. O positive units accounted for 46.9% (1103 units) of emergency transfusions. However, 726 (30.8%) O negative units were transfused to patients without a mandatory indication for O negative blood. Twenty-eight patients (2.9%) had a red cell alloantibody prior to transfusion including anti-E (n = 10), anti-D (n = 4), and anti-K (n = 4). One patient with prior anti-D had mild delayed hemolysis. There were 19 patients (4.3%, median follow-up 22 days) who developed a red cell alloantibody after emergency transfusion and include anti-E (n = 10), anti-D (n = 7), and anti-C (n = 5). DISCUSSION: The use of O positive blood for emergency transfusion has saved 1103 O negative red cell units with no detriment to patient outcome. There remains potential to optimize use of O positive blood in emergency transfusion and to understand red cell alloimmunization rates in a prospective fashion. SN - 1537-2995UR - https://www.unboundmedicine.com/medline/citation/37698202/Quality_improvement_review_of_O_positive_blood_in_emergency_transfusion.DB - PRIMEDP - Unbound MedicineER -
- Authors
- Chowdhury R
- Williams BA
- Williams S
- Casey J
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